Plasma adipokine levels and their association with overall burden of painful joints among individuals with hip and knee osteoarthritis.
| Titel | Plasma adipokine levels and their association with overall burden of painful joints among individuals with hip and knee osteoarthritis. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Perruccio, AV, Mahomed, NN, Chandran, V, Gandhi, R |
| Journal | The Journal of rheumatology |
| Volume | 41 |
| Issue | 2 |
| Pagination | 334-7 |
| Date Published | 2014 Feb |
| ISSN | 0315-162X |
| Schlüsselwörter | Arthrose, Hüftarthrose |
| Zusammenfassung | OBJECTIVE: To investigate the association between plasma adipokine levels and the burden of painful joints among individuals with hip and knee osteoarthritis (OA). METHODS: Adipokines (leptin, adiponectin, adipsin, resistin) were determined by ELISA (n = 78). Individuals reported painful joints on a homunculus. Associations were examined by sex-stratified Poisson analyses. RESULTS: Adjusted for age, body mass index, and hip/knee OA, higher leptin and adiponectin and lower adipsin levels were associated with greater painful joint burden (i.e., counts) among women (p < 0.01). Among men, higher resistin levels were associated with lower counts (p = 0.03). CONCLUSION: Findings support the likelihood of a systemic-dependent sex-specific pain burden among individuals with OA. |
| DOI | 10.3899/jrheum.130709 |
| Alternate Journal | J. Rheumatol. |
| Full Text | |
| PubMed ID | 24334649 |
